Product Overview

5-(4-bromophenyl)-4,6-dichloropyrimidine is an important pharmaceutical intermediate widely used in the synthesis of the antifibrotic drug macitentan, participating as a key structural unit in multiple reaction steps. This product is suitable for small-scale, pilot-scale, and large-scale production in drug development stages, exhibiting good chemical stability and reactivity, and can meet the synthesis needs of different scales. It is one of the important raw materials for pharmaceutical companies in active pharmaceutical ingredient development and process optimization.

Applications

• For the development of synthetic processes for anti-fibrotic drugs such as macitentan
• As a pharmaceutical intermediate for the construction of targeted drug molecules
• Supporting structural modification and functional studies in drug development
• Suitable for process validation in small-scale preparation and pilot-scale amplification stages
• For customized synthesis and process route optimization studies

Quality & Supply Capability

English Name: 5-(4-bromophenyl)-4,6-dichloropyrimidine Properties: White to off-white crystalline powder with a stable aromatic ring structure and halogen substituents. Easily soluble in organic solvents, chemically stable, and suitable for various organic synthesis reaction conditions. Storage Recommendations: Store in a sealed, light-proof, and dry place, referring to the COA/MSDS for specific requirements. Supply Capabilities: Samples, gram-level, kilogram-level, commercial batches. Packaging Specifications: Aluminum foil bags, fluorinated bottles, cardboard drums, customized packaging. Document Support: COA, MSDS, HPLC, NMR, etc. We provide a full-process service from laboratory sample supply to small-scale preparation, pilot-scale amplification, and customized batch production. We can flexibly adjust the supply plan according to the customer's requirements for purity, impurity control, packaging specifications, delivery cycle, and quality documents. Simultaneously, we have a professional technical team to provide customers with comprehensive technical support from laboratory R&D to scale-up production, helping customers efficiently advance process development, route optimization, and project transformation.

Why Choose Bioncan

Focused on pharmaceutical intermediates, possessing extensive synthesis experience and technological expertise. Full-scale supply capability, covering needs from laboratory to commercial production. Provides complete quality control documentation to ensure controllable and traceable product quality. Customized synthesis and process optimization can be implemented according to customer requirements. Comprehensive project scale-up technical support ensures smooth process transformation and implementation.

Online Consulting

For quotation, inventory, samples, COA, MSDS, or custom synthesis support for CAS 146533-41-7, please submit your requirements. We will respond according to purity, quantity, delivery timeline, and documentation needs.